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| First Round Draft Pick History |
| 1 | 4 | 4 | 2000 | Annual Draft | 3B | Travis | Fryman | MLB |
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| 1 | 4 | 4 | 1999 | Annual Draft | P | Alex | Fernandez | MLB |
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| Complete Draft History |
| 1 | 4 | 4 | 2000 | Annual Draft | 3B | Travis | Fryman | MLB |
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| 2 | 3 | 11 | 2000 | Annual Draft | P | Mike | Sirotka | MLB |
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| 3 | 4 | 20 | 2000 | Annual Draft | P | Andy | Benes | MLB |
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| 4 | 4 | 28 | 2000 | Annual Draft | P | Dustin | Hermanson | MLB |
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| 5 | 4 | 36 | 2000 | Annual Draft | 1B | Tino | Martinez | MLB |
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| 6 | 4 | 44 | 2000 | Annual Draft | P | Rich | Garces | MLB |
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| 7 | 4 | 52 | 2000 | Annual Draft | 2B | Denny | Hocking | MLB |
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| 1 | 4 | 4 | 1999 | Annual Draft | P | Alex | Fernandez | MLB |
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| 2 | 4 | 16 | 1999 | Annual Draft | OF | Rusty | Greer | MLB |
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| 2 | 5 | 17 | 1999 | Annual Draft | P | Jose | Rosado | MLB |
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| 3 | 4 | 28 | 1999 | Annual Draft | 2B | Terry | Shumpert | MLB |
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| 4 | 4 | 40 | 1999 | Annual Draft | SS | Rey | Ordonez | MLB |
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| 5 | 4 | 52 | 1999 | Annual Draft | P | Graeme | Lloyd | MLB |
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| 6 | 4 | 64 | 1999 | Annual Draft | P | Rick | Helling | MLB |
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| 7 | 4 | 76 | 1999 | Annual Draft | P | Scott | Sauerbeck | MLB |
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| 8 | 4 | 88 | 1999 | Annual Draft | 1B | Kevin | Young | MLB |
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| 9 | 4 | 100 | 1999 | Annual Draft | OF | Darryl | Hamilton | MLB |
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| 10 | 4 | 112 | 1999 | Annual Draft | P | Steve | Trachsel | MLB |
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| 11 | 4 | 124 | 1999 | Annual Draft | C | Eli | Marrero | MLB |
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