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| First Round Draft Pick History |
| 1 | 7 | 7 | 2001 | Inaugural Draft | OF | Vladimir | Guerrero | MLB |
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| 1 | 5 | 5 | 2000 | Annual Draft | 1B | Mo | Vaughn | MLB |
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| Complete Draft History |
| 1 | 7 | 7 | 2001 | Inaugural Draft | OF | Vladimir | Guerrero | MLB |
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| 2 | 7 | 15 | 2001 | Inaugural Draft | OF | Luis | Gonzalez | MLB |
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| 3 | 7 | 23 | 2001 | Inaugural Draft | P | David | Cone | MLB |
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| 4 | 7 | 31 | 2001 | Inaugural Draft | P | Joe | Mays | MLB |
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| 5 | 7 | 39 | 2001 | Inaugural Draft | P | Mark | Buehrle | MLB |
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| 6 | 7 | 47 | 2001 | Inaugural Draft | 1B | Fred | McGriff | MLB |
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| 7 | 7 | 55 | 2001 | Inaugural Draft | P | Mike | Stanton | MLB |
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| 8 | 7 | 63 | 2001 | Inaugural Draft | 3B | Aramis | Ramirez | MLB |
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| 9 | 7 | 71 | 2001 | Inaugural Draft | C | Damian | Miller | MLB |
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| 10 | 7 | 79 | 2001 | Inaugural Draft | SS | David | Eckstein | MLB |
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| 11 | 7 | 87 | 2001 | Inaugural Draft | SS | Jimmy | Rollins | MLB |
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| 12 | 7 | 95 | 2001 | Inaugural Draft | P | Kazuhiro | Sasaki | MLB |
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| 13 | 7 | 103 | 2001 | Inaugural Draft | P | Bob | Wells | MLB |
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| 1 | 5 | 5 | 2000 | Annual Draft | 1B | Mo | Vaughn | MLB |
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| 2 | 4 | 12 | 2000 | Annual Draft | P | Kevin | Appier | MLB |
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| 3 | 5 | 21 | 2000 | Annual Draft | P | Pat | Hentgen | MLB |
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| 4 | 5 | 29 | 2000 | Annual Draft | P | Javier | Vazquez | MLB |
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| 5 | 5 | 37 | 2000 | Annual Draft | P | Jeff | Tam | MLB |
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| 6 | 5 | 45 | 2000 | Annual Draft | SS+ | Julio | Lugo | MLB |
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| 7 | 5 | 53 | 2000 | Annual Draft | 2B+ | Jose | Offerman | MLB |
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